(61) Control of the transition from sensory detection to sensory awareness in man by the duration of a thalamic stimulus. The cerebral "time-on" factor. Libet B, Pearl DK, Morledge DE, Gleason CA, Hosobuchi Y and Barbaro NM. 1991. Brain, volume 114, pages 1731-1757.
Were the subjects trying to please the researchers? Were the researchers who elicited "Detection" and "Awareness" unaware of whether stimuli had been delivered, and, if unaware, were they tested for their awareness through forced choice guesses? Did medication alter thresholds? Why was electroencephalography not used as an objective measure of detection and, or awareness?
(62) New intrathalamic pathways allowing modality-related and cross-modality switching in the dorsal thalamus. Crabtree JW and Isaac JT. 2002. Journal of Neuroscience, volume 22, pages 8754-8761.
With reference to trying not to find what they were looking for, the researchers stated that: "The IPSCs were always substantially larger than spontaneous IPSCs, if present, and were evoked with a constant latency typically between 50 and 100msec relative to the frequency of the glutamate pulse." Why was the difference in amplitude between evoked and spontaneous IPSCs not tested for statistical significance? Why was the rate of spontaneous IPSCs not reported? Why were there no images enabling comparisons of evoked and spontaneous IPSCs?
With reference to changes in tense, the researchers used the present tense unequivocally in the discussion, thereby generalising their findings in spite of the limitations of the "in vitro" format, which they did not acknowledge.
(63) Properties of primary sensory (lemniscal) synapses in the ventrobasal thalamus and the relay of high-frequency sensory inputs. Castro-Alamancos MA. 2002. Journal of Neurophysiology, volume 87, pages 946-953.
With reference to hyperbole, the opening sentence of the abstract: "The main role of the thalamus is to relay sensory inputs to the neocortex." is provocative. The thalamus orchestrates sensory, motor and visceral activities, as evidenced by its many nuclei, and if the researcher believed that these activities could be ranked, then he should have presented evidence to support his view.
With reference to trying not to find what he was looking for, the researcher's results for acetylcholine included p<0.0001; n=3 and for norepinephrine p<0.0001; n=4, which findings were described in the present tense as having general application. The similarity of effects of acetylcholine and norepinephrine suggested that they might have been due to the experimental format, which the researcher did not discuss.
(64) Corticofugal gating of auditory information in the thalamus: an in vivo intracellular recording study. Yu YQ, Xiong Y, Chan YS and He J. 2004. Journal of Neuroscience, volume 24, pages 3060-3069.
With reference to animal experimentation, were the procedures to which the guinea pigs were subjected approved ethically?
With reference to consistent language: "Four of the five neurons located in the ventral division of the MGB (MGv) received facilitatory modulation from the cortical stimulation and the remainder did not respond to the cortical stimulation." Why not just say that one neurone did not respond? Again: "Of the four neurons that were histologically confirmed to be in the non-lemniscal MGB, three showed an inhibitory response to the acoustic stimulus, and one responded with spikes and EPSPs to the auditory stimulus." What was the difference between the acoustic stimulus and the auditory stimulus?
With reference to conclusions extending beyond results, the distinction between the "lemniscal" and "non-lemniscal" MGB was based on a sample of nine neurones, but the researchers do not indicate from how many guinea pigs these nine neurones were derived.
(65) Analysis of spontaneous activity patterns of human thalamic ventrolateral neurons and their modifications due to functional brain changes. Raeva S, Vainberg N and Dubinin V. 1999. Neuroscience, volume 88, pages 365-376.
(66) Analysis of evoked activity patterns of human thalamic ventrolateral neurons during verbally ordered voluntary movements. Raeva S, Vainberg N, Tikhonov Y and Tsetlin I. 1999. Neuroscience, volume 88, pages 377-392.
(67) Afferent projections to nucleus reuniens of the thalamus. McKenna JT and Vertes RP. 2004. Journal of Comparative Neurology, volume 480, pages 115-142.
(68) Neuronal activity in the primate motor thalamus during visually triggered and internally generated limb movements. van Donkelaar P, Stein JF, Passingham RE and Miall RC. 1999. Journal of Neurophysiology, volume 82, pages 934-945.
With reference to incorrect punctuation: "In contrast to this, relatively high degree of task specificity, in both VPLo and VLo the largest group of cells (approximately 55%) burst in relation to both tasks." There should be no comma after "this", and there should be a comma after VLo, and these mistakes visually trigger uncertainty.
With reference to the use of a singular noun with a plural verb, below Fig. 4. in the main text "...the largest group of cells were active" appears twice.
(69) Temporary inactivation in the primate motor thalamus during visually triggered and internally generated limb movements. van Donkelaar P, Stein JF, Passingham RE and Miall RC. 2000. Journal of Neurophysiology, volume 83, pages 2780-2790.
With reference to the lack of controls, and to how hard the researchers tried not to find what they were looking for, these researchers did not use control injections of lignocaine 5% into other thalamic nuclei, in spite of the realisation that the injected lignocaine might spread.
With reference to wishes conveyed by italics, specific subcircuits appeared for the first time in the discussion, as the concerns about the spread of lignocaine 5% were being admitted.
(70) Toward an agreement on terminology of nuclear and subnuclear divisions of the motor thalamus. Macchi G and Jones EG. 1997. Journal of Neurosurgery, volume 86, pages 670-685.